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Placenta. 2015 Jan;36(1):88-92. doi: 10.1016/j.placenta.2014.11.005. Epub 2014 Nov 15.

Endoplasmic reticulum stress is induced in the human placenta during labour.

Author information

1
Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, UK; University Medical Center Utrecht, Division of Perinatology, Department of Obstetrics, The Netherlands. Electronic address: jhwv2@cam.ac.uk.
2
Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, UK.

Abstract

Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to labour represents an in vivo model for the study of acute placental ER stress. ER stress markers, GRP78, P-eIF2α and XBP-1, were significantly higher in laboured placentas than in Caesarean-delivered controls localised mainly in the syncytiotrophoblast. The similarities to changes observed in PE/IUGR placentas suggest exposure to labour can be used to investigate induction of ER stress in pathological placentas.

KEYWORDS:

Endoplasmic reticulum stress; Labour; Placenta

PMID:
25434970
PMCID:
PMC4302217
DOI:
10.1016/j.placenta.2014.11.005
[Indexed for MEDLINE]
Free PMC Article

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