Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Res. 1989 May 8;486(2):297-300.

Long-lasting effects of naltrexone, an opioid receptor antagonist, on cell proliferation in developing rat forebrain.

Author information

1
Institute of Pathology, Gesellschaft für Strahlen- und Umweltforschung mbH München, Neuherberg, F.R.G.

Abstract

Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the proliferation of the 4-12-week-old rat forebrain subependymal layer. We found that naltrexone, when given daily throughout the weaning period, evoked a long-lasting increase of the mitotic rate and the [3H]thymidine labelling index. This effect was most significant about 8-10 weeks after ending the naltrexone treatment. Although a direct influence of naltrexone on long-term subependymal cell proliferation cannot be excluded, we are discussing evidence of an indirect effect via suppression of noradrenergic activity in the forebrain.

PMID:
2543480
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center