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Biochim Biophys Acta. 1989 Jun 8;1003(2):121-4.

The urine from patients with peritonitis as a rich source for purifying human acid sphingomyelinase and other lysosomal enzymes.

Author information

1
Institut für Organische Chemie und Biochemie, Universität Bonn, F.R.G.

Abstract

Milligram amounts of human acid sphingomyelinase (EC 3.1.4.12) were purified to 95% homogeneity using urine from patients with acute peritonitis. The activity of this enzyme is elevated more than 200-times in the urine of these patients. To a lesser extent, levels of some other lysosomal hydrolases are also elevated.

PMID:
2543449
DOI:
10.1016/0005-2760(89)90244-0
[Indexed for MEDLINE]

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