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Nat Cell Biol. 2014 Dec;16(12):1132-3. doi: 10.1038/ncb3078.

Sugar modification inhibits autophagosome-lysosome fusion.

Author information

1
Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

Abstract

Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals.

PMID:
25434465
DOI:
10.1038/ncb3078
[Indexed for MEDLINE]

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