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Cytokine Growth Factor Rev. 2015 Feb;26(1):25-33. doi: 10.1016/j.cytogfr.2014.10.009. Epub 2014 Oct 31.

An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17.

Author information

1
Inflammation Research Center, VIB, Ghent, Belgium; Department Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
2
Inflammation Research Center, VIB, Ghent, Belgium; Department Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: Roosmarijn.Vandenbroucke@irc.VIB-UGent.be.

Abstract

Psoriasis is a skin disease where various cytokines play a detrimental role, yet our understanding of the disease is still limited. TNF is a validated drug target in psoriasis and other autoimmune diseases, but its use is associated with side effects. Some paradoxical side effects of anti-TNF treatment are supposedly associated with type I IFNs, which are also implicated in the pathogenesis of psoriasis. Recently, the IL-23/IL-17 axis has been associated with psoriasis as well, and new drugs targeting this axis have already been developed. Findings suggest that these cytokines are interwoven. We discuss recent findings reinforcing the role of TNF, Type I IFNs and IL-17 in the pathogenesis of psoriasis and the apparent inflammatory interplay between these three cytokines.

KEYWORDS:

IL-17/IL-23; Psoriasis; TNF; Tumor necrosis factor; Type I interferons

PMID:
25434285
DOI:
10.1016/j.cytogfr.2014.10.009
[Indexed for MEDLINE]

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