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Adv Physiol Educ. 2014 Dec;38(4):308-14. doi: 10.1152/advan.00080.2014.

Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle.

Author information

1
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts kristin.stanford@joslin.harvard.edu.
2
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Abstract

Exercise is a well-established tool to prevent and combat type 2 diabetes. Exercise improves whole body metabolic health in people with type 2 diabetes, and adaptations to skeletal muscle are essential for this improvement. An acute bout of exercise increases skeletal muscle glucose uptake, while chronic exercise training improves mitochondrial function, increases mitochondrial biogenesis, and increases the expression of glucose transporter proteins and numerous metabolic genes. This review focuses on the molecular mechanisms that mediate the effects of exercise to increase glucose uptake in skeletal muscle.

KEYWORDS:

exercise; type 2 diabetes

PMID:
25434013
PMCID:
PMC4315445
DOI:
10.1152/advan.00080.2014
[Indexed for MEDLINE]
Free PMC Article

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