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Chemosphere. 2015 Jan;118:1-4. doi: 10.1016/j.chemosphere.2014.05.026. Epub 2014 Jun 7.

Levels of PCDDs, PCDFs and dl-PCBs in the blood of childbearing-aged women living in the vicinity of a chemical plant in Tianjin: a primary study.

Author information

1
Dept. of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, 22 Qi Xiang Tai Road, Heping District, Tianjin 300070, China.
2
Key Lab for Food Safety and Risk Assessment, Ministry of Public Health & China Center for Food Safety Risk Assessment, 7 Panjiayuan Nan Li, Chao Yang District, Beijing 100021, China.
3
Vaccine & Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
4
Key Lab of Chemical Safety and Health, Chinese Center for Disease Control and Prevention & National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, 27 Nan Wei Road, West City District, Beijing 100050, China. Electronic address: sunxin@chinacdc.cn.
5
Dept. of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, 22 Qi Xiang Tai Road, Heping District, Tianjin 300070, China. Electronic address: tangnaijun@tijmu.edu.cn.

Abstract

Several studies have suggested that maternal exposure to Polychlorinated dibenzo-p-dioxins (PCDDs), poly-chlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs) may affect foetal growth and infant development. The aim of our study was to determine whether the childbearing-aged residents living near a chemical plant have a greater exposure risk. Concentrations of 17 PCDD/Fs congeners and 12 non-ortho and mono-ortho dioxin-like PCBs were measured using HRGC-HRMS in the blood of 30 non-occupational childbearing-aged women living near a chemical plant (Dagu) that had been producing chlorinated pesticides from 1958 to 2004. The factors that influenced the body burden were investigated based on responses to a questionnaire. Levels of PCDD/Fs+PCBs were in the range of 16.43-155.29pg WHO 2005-TEQg(-1) lipid. PCDDs and PCDFs contributed 56.72% and 34.44%, respectively, to the total TEQ value. Total WHO-TEQ was approximately tenfold higher in the participants living in the vicinity of the plant (distance: 1.52±0.148km) than in the groups living farther away (distance: 4.93±1.124km). A negative correlation between total WHO-TEQ and distance to Dagu was observed by multiple linear regression models. The data provide basic information for monitoring dioxin-like chemicals in the district and for the future study of the relationship between POPs and pregnancy outcomes.

KEYWORDS:

Chemical Plant; Childbearing-aged Women; Dioxins; PCDDs; PCDFs; dl-PCBs

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