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J Physiol. 2015 Sep 15;593(18):4085-90. doi: 10.1113/jphysiol.2014.286260. Epub 2015 Jan 5.

In the beginning: a personal reminiscence on the origin and legacy of ClC-0, the 'Torpedo Cl(-) channel'.

Author information

1
Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA, USA.

Abstract

This unapologetically subjective essay recalls the Torpedo Cl(-) channel in the years when it had neither a molecular identity nor proper name (ClC-0), and membership in a large superfamily. I discuss the circumstances surrounding its discovery and subsequent research through the 1980s that revealed its unusual molecular architecture and other strange mechanistic characteristics.

PMID:
25433078
PMCID:
PMC4594285
DOI:
10.1113/jphysiol.2014.286260
[Indexed for MEDLINE]
Free PMC Article

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