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Urology. 2014 Dec;84(6):1347-50. doi: 10.1016/j.urology.2014.09.004.

Seminal Helicobacter pylori treatment improves sperm motility in infertile asthenozoospermic men.

Author information

1
Dermatology, Venereology & Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
2
Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
3
Department of Andrology & Sexology, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: taymour1155@link.net.

Abstract

OBJECTIVE:

To assess the effect of treatment of seminal Helicobacter pylori in infertile asthenozoospermic men.

METHODS:

In all, 223 infertile asthenozoospermic men were consecutively selected. They were subjected to history taking, clinical examination, semen analysis, and estimation of H pylori IgA antibodies in their seminal fluid. Infertile men with high seminal H pylori IgA were subjected to triple drug treatment, omeprazole, 20 mg; tinidazole, 500 mg; and clarithromycin, 250 mg twice a day for 2 weeks. Semen analysis as well as H pylori IgA antibodies was estimated after 3 months.

RESULTS:

In all, 22 of 223 men (9.87%) demonstrated H pylori IgA antibodies in their seminal plasma. After treatment, mean seminal H pylori IgA levels demonstrated significant decrease (1.55 ± 0.4 vs 0.52 ± 0.26; 95% confidence interval, 0.83-1.21; P = .001) concomitant with improved progressive as well as nonprogressive sperm motility. H pylori IgA antibodies demonstrated significant negative correlation with progressive sperm motility, nonprogressive sperm motility, normal sperm morphology, and significant positive correlation with immotile sperm motility.

CONCLUSION:

H pylori treatment significantly improves sperm motility in infertile asthenozoospermic men with elevated seminal H pylori IgA.

PMID:
25432826
DOI:
10.1016/j.urology.2014.09.004
[Indexed for MEDLINE]

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