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Bull Exp Biol Med. 2014 Dec;158(2):219-21. doi: 10.1007/s10517-014-2726-3. Epub 2014 Nov 29.

Effect of GABA derivatives on the rate of thrombus formation, platelet aggregation, and plasma coagulation capacity in rats with experimental gestosis.

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Department of Pharmacology and Biopharmacy, Doctors Improvement Faculty, Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia.


Experimental gestosis induced by replacement of drinking water with 1.8% NaCl promoted hypercoagulation, increased the rate and degree of platelet aggregation, and reduced clotting time in pregnant females. GABA derivatives, compounds RGPU-151, RGPU-152, and phenibut normalized parameters of hemostasis and platelet aggregation and the rate of thrombus formation in the animals. The efficiency of the test substances did not significantly differ from that of the reference drug sulodexide.

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