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Neurosurg Clin N Am. 2015 Jan;26(1):91-8. doi: 10.1016/j.nec.2014.09.003. Epub 2014 Oct 18.

Atypical and rare variants of central neurocytomas.

Author information

1
Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive MC5327, Stanford, CA 94305, USA.
2
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr, R241 MC 5324, Stanford, CA 94305, USA.
3
Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive MC5327, Stanford, CA 94305, USA. Electronic address: gordonli@stanford.edu.

Abstract

This article reviews the variation in imaging, histopathology, clinical course, and management seen with central neurocytomas (CNs). CNs have often been misdiagnosed as oligodendrogliomas and ependymomas; however, synaptophysin positivity can correctly diagnose these neurocytic neoplasms. Atypical CNs, an important variant first described in 1997, are marked by increased proliferative potential and associated with worse clinical outcomes in terms of long-term survival and local tumor control. Complete surgical resection is the cornerstone of therapy, and postoperative radiation is recommended in the setting of residual disease. Other less aggressive variants of central neurocytomas, including liponeurocytomas, ganglioneurocytomas, and pigmented neurocytomas, are also discussed.

KEYWORDS:

Anaplastic; Atypical; Central neurocytoma; Ganglioneurocytoma; Liponeurocytoma; MIB-1

PMID:
25432187
DOI:
10.1016/j.nec.2014.09.003
[Indexed for MEDLINE]

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