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Mar Drugs. 2014 Nov 26;12(12):5719-63. doi: 10.3390/md12125719.

Alternative methods for the detection of emerging marine toxins: biosensors, biochemical assays and cell-based assays.

Author information

1
IRTA, Carretera Poble Nou km 5.5, 43540 Sant Carles de la Ràpita, Spain. laia.reverte@irta.cat.
2
IRTA, Carretera Poble Nou km 5.5, 43540 Sant Carles de la Ràpita, Spain. lucia.solino@irta.cat.
3
IRTA, Carretera Poble Nou km 5.5, 43540 Sant Carles de la Ràpita, Spain. olga.carnicer@irta.cat.
4
IRTA, Carretera Poble Nou km 5.5, 43540 Sant Carles de la Ràpita, Spain. jorge.diogene@irta.cat.
5
IRTA, Carretera Poble Nou km 5.5, 43540 Sant Carles de la Ràpita, Spain. monica.campas@irta.cat.

Abstract

The emergence of marine toxins in water and seafood may have a considerable impact on public health. Although the tendency in Europe is to consolidate, when possible, official reference methods based on instrumental analysis, the development of alternative or complementary methods providing functional or toxicological information may provide advantages in terms of risk identification, but also low cost, simplicity, ease of use and high-throughput analysis. This article gives an overview of the immunoassays, cell-based assays, receptor-binding assays and biosensors that have been developed for the screening and quantification of emerging marine toxins: palytoxins, ciguatoxins, cyclic imines and tetrodotoxins. Their advantages and limitations are discussed, as well as their possible integration in research and monitoring programs.

PMID:
25431968
PMCID:
PMC4278199
DOI:
10.3390/md12125719
[Indexed for MEDLINE]
Free PMC Article

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