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ScientificWorldJournal. 2014;2014:239508. doi: 10.1155/2014/239508. Epub 2014 Nov 5.

Antimetastatic and anti-inflammatory potentials of essential oil from edible Ocimum sanctum leaves.

Author information

1
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
2
Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu 641029, India.

Abstract

Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant ((*) P < 0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer.

PMID:
25431779
PMCID:
PMC4238170
DOI:
10.1155/2014/239508
[Indexed for MEDLINE]
Free PMC Article

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