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Int J Mol Sci. 2014 Nov 25;15(12):21674-86. doi: 10.3390/ijms151221674.

Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto's thyroiditis.

Author information

1
Department of Laboratory Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, China. zjliuyingzhao@126.com.
2
Institute of Laboratory Medicine, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China. xinyitang0301@sina.com.
3
Institute of Laboratory Medicine, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China. tjj850913@163.com.
4
Institute of Laboratory Medicine, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China. zcl51234@163.com.
5
Department of Laboratory Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, China. penghuiyong33815@163.com.
6
Institute of Laboratory Medicine, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China. j827864988@163.com.
7
Institute of Laboratory Medicine, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China. wyg1223@126.com.
8
Institute of Laboratory Medicine, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China. mcm20040901@126.com.
9
Institute of Laboratory Medicine, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China. zjflmj19780723@126.com.
10
Department of Pathology and Centre of Infection and Immunology, The University of Hong Kong, Hong Kong 999077, China. liweilu@hkucc.hku.hk.
11
Institute of Laboratory Medicine, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China. xuhx@ujs.edu.cn.
12
Department of Laboratory Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, China. sjwjs@ujs.edu.cn.

Abstract

Hashimoto's thyroiditis (HT) is an organ-specific immune disease characterized by the presence of lymphocytic infiltration and serum autoantibodies. Previous studies have confirmed the critical role of Th17 cells in the pathopoiesis of HT patients. Additionally, regulatory T cells (Treg) display a dysregulatory function in autoimmune disease. The purpose of this study is to investigate the alteration of Th17 and Treg cells in HT patients and explore contributing factors. We found there was an increased ratio of Th17/Treg in HT patients and a positive correlation with autoantibodies (anti-TgAb). In addition, there was an increased level of GITRL, which has been demonstrated to be correlated with the increassement of Th17 cells in the serum and thyroid glands of HT patients; the upregulated serum level of GITRL has a positive correlation with the percentage of Th17 cells in HT patients. In summary, an increase in GITRL may impair the balance of Th17/Treg, and contribute to the pathopoiesis of Hashimoto's thyroiditis.

PMID:
25429429
PMCID:
PMC4284671
DOI:
10.3390/ijms151221674
[Indexed for MEDLINE]
Free PMC Article

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