Format

Send to

Choose Destination
J Neurosci. 2014 Nov 26;34(48):16058-64. doi: 10.1523/JNEUROSCI.3382-14.2014.

Precise detection of direct glomerular input duration by the olfactory bulb.

Author information

1
Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences/State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan, China 430071.
2
Department of Molecular and Cellular Biology, and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, and.
3
Department of Neurobiology, Northwestern University, Evanston, Illinois 60208.
4
Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, diego.restrepo@ucdenver.edu.

Abstract

Sensory neuron input to the olfactory bulb (OB) was activated precisely for different durations with blue light in mice expressing channelrhodopsin-2 in olfactory sensory neurons. Behaviorally the mice discriminated differences of 10 ms in duration of direct glomerular activation. In addition, a subset of mitral/tufted cells in the OB of awake mice responded tonically therefore conveying information on stimulus duration. Our study provides evidence that duration of the input to glomeruli not synchronized to sniffing is detected. This potent cue may be used to obtain information on puffs in odor plumes.

KEYWORDS:

olfactory; puffs

PMID:
25429146
PMCID:
PMC4244471
DOI:
10.1523/JNEUROSCI.3382-14.2014
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center