Format

Send to

Choose Destination
Immunotherapy. 2014;6(10):1055-71. doi: 10.2217/imt.14.81.

Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy?

Author information

1
Neural Dynamics Research Group, 828 W. 10th Ave, Vancouver, BC, V5Z 1L8, Canada.

Abstract

In spite of a common view that aluminum (Al) salts are inert and therefore harmless as vaccine adjuvants or in immunotherapy, the reality is quite different. In the following article we briefly review the literature on Al neurotoxicity and the use of Al salts as vaccine adjuvants and consider not only direct toxic actions on the nervous system, but also the potential impact for triggering autoimmunity. Autoimmune and inflammatory responses affecting the CNS appear to underlie some forms of neurological disease, including developmental disorders. Al has been demonstrated to impact the CNS at every level, including by changing gene expression. These outcomes should raise concerns about the increasing use of Al salts as vaccine adjuvants and for the application as more general immune stimulants.

KEYWORDS:

CNS; adjuvant; aluminum; autoimmunity; neurodegeneration; toxicity

PMID:
25428645
DOI:
10.2217/imt.14.81
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center