Consanguinity in India and its association with autism spectrum disorder

Madhu P Mamidala; Mahesh K Kalikiri; P T V Praveen Kumar; N Rajesh; OmSai R Vallamkonda; Vidya Rajesh

doi:10.1002/aur.1431

Consanguinity in India and its association with autism spectrum disorder

Autism Res. 2015 Apr;8(2):224-8. doi: 10.1002/aur.1431. Epub 2014 Nov 26.

Authors

Madhu P Mamidala¹, Mahesh K Kalikiri, P T V Praveen Kumar, N Rajesh, OmSai R Vallamkonda, Vidya Rajesh

Affiliation

¹ Department of Biological Sciences, Birla Institute of Technology and Science, Hyderabad, India.

PMID: 25428403
DOI: 10.1002/aur.1431

Abstract

Autism Spectrum Disorder (ASD) has both genetic and environmental factors in its etiology. The risk for many disorders is increased by consanguinity, but it is not known whether it increases the risk for ASD. Our study from large population in India concludes that consanguinity increases the risk for ASD with an odds ratio of 3.22.

Keywords: Autism Spectrum Disorder; India; consanguinity; genetic association; risk factors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autism Spectrum Disorder / epidemiology*
Causality
Child
Child, Preschool
Consanguinity*
Female
Humans
India / epidemiology
Male
Odds Ratio
Psychometrics
Risk Factors
Surveys and Questionnaires