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J Virol. 1989 Jul;63(7):3161-3.

Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus.

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1
Department of Virology, Research Institute for Microbial Diseases, Osaka University, Japan.

Abstract

Human herpesvirus 6 (HHV-6)-related virus was isolated from CD4+ CD8- and CD3+ CD4+ mature T lymphocytes but could not be isolated from CD4- CD8+, CD4- CD8-, and CD3- T cells in the peripheral blood of exanthem subitum patients. HHV-6-related virus predominantly infected CD4+ CD8+, CD4+ CD8-, and CD3+ CD4+ cells with mature phenotypes and rarely infected CD4- CD8+ cells from cord blood mononuclear cells, which suggested predominant CD4 mature T-lymphocyte tropism of HHV-6-related virus.

PMID:
2542623
PMCID:
PMC250875
[Indexed for MEDLINE]
Free PMC Article
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