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Behav Brain Funct. 2014 Nov 25;10:43. doi: 10.1186/1744-9081-10-43.

The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder.

Author information

1
Deparment of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea. soochurl@snu.ac.kr.

Abstract

BACKGROUND:

We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is affected by the brain-derived neurotrophic factor (BDNF) val66met polymorphism.

METHODS:

The participants included 92 patients with ADHD aged 6-15 years. Measures of parenting in early life and externalizing and internalizing symptoms and the genotype of the BDNF Val66Met polymorphism were obtained.

RESULTS:

The degree to which the baby's autonomy was allowed was significantly and negatively correlated with the CDI scores in ADHD children (r = -0.38, p = 0.005). After adjusting for the child's gender, the child's age, the family's gross annual income, and the maternal education level, there was a significant interaction for the BDNF genotype and mother's positive feelings about caring in relation to the development of childhood anxiety/depression in ADHD children (F = 2.51, p = 0.011).

CONCLUSIONS:

Our results provide evidence of an interaction between the BDNF met allele and early parenting on the development of depression/anxiety symptoms.

PMID:
25425456
PMCID:
PMC4289369
DOI:
10.1186/1744-9081-10-43
[Indexed for MEDLINE]
Free PMC Article

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