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J Fish Biol. 2015 Jan;86(1):402-8. doi: 10.1111/jfb.12568. Epub 2014 Nov 26.

Efficiency of the inbreeding coefficient f and other estimators in detecting null alleles, as revealed by empirical data of locus oke3 across 65 populations of chum salmon Oncorhynchus keta.

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N.I. Vavilov Institute of General Genetics, 3 Gubkin St, Moscow, 119991, Russia.


A survey of 65 populations of chum salmon Oncorhynchus keta across the species range revealed homozygote excess (947 homozygotes in 2954 fish) at a polymerase chain reaction (PCR)-based simple sequence repeat (SSR) locus oke3 with multiple alleles, whereas re-designed PCR primers indicated that 328 of these homozygotes were actually heterozygotes. Statistically significant high positive values of inbreeding coefficients, f, in multiple populations appeared to be a reliable predictor of null alleles. Based on these data, three methods were checked for their ability to estimate null-allele frequencies.


DNA amplification; SNP; f-value; null allele; population study

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