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Dig Dis Sci. 2015 May;60(5):1232-5. doi: 10.1007/s10620-014-3450-6. Epub 2014 Nov 26.

Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.

Author information

1
Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing, 210008, China.

Abstract

BACKGROUND:

Previous studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigate the influence of CYP2B6 polymorphism on susceptibility of Hirschsprung disease.

METHODS:

TaqMan assay was performed to determine the genotypes of CYP2B6 rs707265, rs1042389, rs2054675 in 262 cases and 290 control subjects. Logistic regression was used to assess the associations between these polymorphisms and HSCR.

RESULTS:

We observed a significant association of CYP2B6 rs707265 (G>A) polymorphism and HSCR susceptibility (p < 0.001). Besides, rs707265 A presented a significant risk of HSCR (p < 0.001).

CONCLUSIONS:

Our result suggested that CYP2B6 rs707265 modified the risk of HSCR.

PMID:
25424204
PMCID:
PMC4427616
DOI:
10.1007/s10620-014-3450-6
[Indexed for MEDLINE]
Free PMC Article

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