Complete nucleotide sequences of two NDM-1-encoding plasmids from the same sequence type 11 Klebsiella pneumoniae strain

Antimicrob Agents Chemother. 2015 Feb;59(2):1325-8. doi: 10.1128/AAC.04095-14. Epub 2014 Nov 24.

Abstract

The sequence type 11 Klebsiella pneumoniae strain Kpn-3002cz was confirmed to harbor two NDM-1-encoding plasmids, pB-3002cz and pS-3002cz. pB-3002cz (97,649 bp) displayed extensive sequence similarity with the blaNDM-1-carrying plasmid pKPX-1. pS-3002cz (73,581 bp) was found to consist of an IncR-related sequence (13,535 bp) and a mosaic region (60,046 bp). A 40,233-bp sequence of pS-3002cz was identical to the mosaic region of pB-3002cz, indicating the en bloc acquisition of the NDM-1-encoding region from one plasmid by the other.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Klebsiella pneumoniae / genetics*
  • Plasmids / genetics*
  • beta-Lactamases / genetics*

Substances

  • beta-Lactamases
  • beta-lactamase NDM-1