Format

Send to

Choose Destination
Ann Intern Med. 2015 Jan 20;162(2):109-22. doi: 10.7326/M14-1659.

Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force.

Abstract

BACKGROUND:

Vitamin D deficiency has been associated with adverse health outcomes.

PURPOSE:

To systematically review benefits and harms of vitamin D screening in asymptomatic adults.

DATA SOURCES:

Ovid MEDLINE (through the third week of August 2014), Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews.

STUDY SELECTION:

Randomized trials of screening for and treatment of vitamin D deficiency and case-control studies nested within the Women's Health Initiative.

DATA EXTRACTION:

One investigator abstracted data, a second reviewed data for accuracy, and 2 investigators independently assessed study quality using predefined criteria.

DATA SYNTHESIS:

No study examined the effects of vitamin D screening versus no screening on clinical outcomes. Vitamin D treatment was associated with decreased mortality versus placebo or no treatment (11 studies; risk ratio [RR], 0.83 [95% CI, 0.70 to 0.99]), although benefits were no longer seen after trials of institutionalized persons were excluded (8 studies; RR, 0.93 [CI, 0.73 to 1.18]). Vitamin D treatment was associated with possible decreased risk for having at least 1 fall (5 studies; RR, 0.84 [CI, 0.69 to 1.02]) and falls per person (5 studies; incidence rate ratio, 0.66 [CI, 0.50 to 0.88]) but not fractures (5 studies; RR, 0.98 [CI, 0.82 to 1.16]). Vitamin D treatment was not associated with a statistically significant increased risk for serious adverse events (RR, 1.17 [CI, 0.74 to 1.84]).

LIMITATION:

Variability across studies in 25-hydroxyvitamin D assays and baseline levels, treatment doses, use of calcium, and duration of follow-up.

CONCLUSION:

Treatment of vitamin D deficiency in asymptomatic persons might reduce mortality risk in institutionalized elderly persons and risk for falls but not fractures.

PRIMARY FUNDING SOURCE:

Agency for Healthcare Research and Quality.

Comment in

PMID:
25419719
DOI:
10.7326/M14-1659
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center