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Physica A. 2015 Jan 15;418:126-153.

Biophysics of protein-DNA interactions and chromosome organization.

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Department of Physics & Astronomy and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois USA 60208.


The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein-DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.


DNA; DNA-protein interactions; chromosome dynamics; chromosome structure

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