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Nat Rev Microbiol. 2015 Jan;13(1):28-41. doi: 10.1038/nrmicro3367. Epub 2014 Nov 24.

At the centre: influenza A virus ribonucleoproteins.

Author information

1
School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA.
2
1] School of Veterinary Medicine, Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, 575 Science Drive, Madison, Wisconsin 53711, USA. [2] Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. [3] ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan. [4] Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

Abstract

Influenza A viral ribonucleoprotein (vRNP) complexes comprise the eight genomic negative-sense RNAs, each of which is bound to multiple copies of the vRNP and a trimeric viral polymerase complex. The influenza virus life cycle centres on the vRNPs, which in turn rely on host cellular processes to carry out functions that are necessary for the successful completion of the virus life cycle. In this Review, we discuss our current knowledge about vRNP trafficking within host cells and the function of these complexes in the context of the virus life cycle, highlighting how structure contributes to function and the crucial interactions with host cell pathways, as well as on the information gaps that remain. An improved understanding of how vRNPs use host cell pathways is essential to identify mechanisms of virus pathogenicity, host adaptation and, ultimately, new targets for antiviral intervention.

PMID:
25417656
PMCID:
PMC5619696
DOI:
10.1038/nrmicro3367
[Indexed for MEDLINE]
Free PMC Article

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