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Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.

Geroscience: linking aging to chronic disease.

Author information

1
Buck Institute for Research on Aging, Novato, CA USA. Electronic address: bkennedy@buckinstitute.org.
2
Penn Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology and Department of Genetics and Department of Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
3
Department of Genetics, Stanford University, Stanford, CA 94305, USA; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.
4
Buck Institute for Research on Aging, Novato, CA USA; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
5
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
6
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA.
7
IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy; C.I.G., Interdepartmental Center 'L. Galvani' for Integrated Studies on Bioinformatics, Biophysics, and Biocomplexity, University of Bologna, 3 Bologna, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 3 Bologna, Italy.
8
Buck Institute for Research on Aging, Novato, CA USA.
9
Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
10
Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
11
Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
12
Donald W Reynolds Endowed Chair of Aging Research, Professor of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA; Oklahoma City VA Medical Center, Oklahoma City, OK 73104, USA.
13
Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences and the Icahn Institute for Genomics and Multiscale Biology, New York, NY 10029, USA.
14
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
15
Division of Aging Biology, National Institute on Aging, Bethesda, MD 20892, USA.

Abstract

Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.

PMID:
25417146
PMCID:
PMC4852871
DOI:
10.1016/j.cell.2014.10.039
[Indexed for MEDLINE]
Free PMC Article

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