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Cell. 2014 Oct 23;159(3):487-98. doi: 10.1016/j.cell.2014.09.054.

Building robust transcriptomes with master splicing factors.

Author information

1
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: sharppa@mit.edu.

Abstract

Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development.

PMID:
25417102
PMCID:
PMC4243530
DOI:
10.1016/j.cell.2014.09.054
[Indexed for MEDLINE]
Free PMC Article

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