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Cell. 2014 Nov 20;159(5):973-974. doi: 10.1016/j.cell.2014.11.009.

Genetic variation meets replication origins.

Author information

1
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
2
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: shendure@uw.edu.

Abstract

Genome replication programs are highly orchestrated. In this issue, Koren and colleagues leverage whole-genome sequencing data to discover that DNA replication timing patterns differ between individuals and are associated with genetic variants. These so-called rtQTLs represent a new form of quantitative trait loci that may influence gene dosage and mutational frequency and provide mechanistic insights into the regulation of DNA replication.

PMID:
25416936
DOI:
10.1016/j.cell.2014.11.009
[Indexed for MEDLINE]
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