Format

Send to

Choose Destination
Mol Neurobiol. 2016 Jan;53(1):155-162. doi: 10.1007/s12035-014-8979-z. Epub 2014 Nov 23.

Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome.

Author information

1
Department of Molecular Biology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA. narayan.ramakrishna@gmail.com.
2
Department of Virology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.
3
Department of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.

Abstract

Alpha-synuclein (SNCA), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of SNCA promoter proximal CpG sites and expression in Ts65Dn mice. These results suggest a positive link between CpG methylation and SNCA expression in Down syndrome.

KEYWORDS:

Alpha-synuclein; Demethylation; Down syndrome; EGCG; Ts65Dn mice

PMID:
25416858
DOI:
10.1007/s12035-014-8979-z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center