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Nucleic Acids Res. 2015 Jan;43(Database issue):D153-9. doi: 10.1093/nar/gku1215. Epub 2014 Nov 21.

DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions.

Author information

1
DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece Laboratory for Experimental Surgery and Surgical Research 'N.S. Christeas', Medical School of Athens, University of Athens, 11527 Athens, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.
2
DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
3
'Athena' Research and Innovation Center, 11524 Athens, Greece.
4
'Athena' Research and Innovation Center, 11524 Athens, Greece School of Electrical and Computer Engineering, NTUA, 15773 Zografou, Greece.
5
Department of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
6
Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece.
7
'Athena' Research and Innovation Center, 11524 Athens, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.
8
DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.

Abstract

microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of miRNA:gene interactions have been experimentally identified. However, this wealth of information is fragmented and hidden in thousands of manuscripts and raw next-generation sequencing data sets. DIANA-TarBase was initially released in 2006 and it was the first database aiming to catalog published experimentally validated miRNA:gene interactions. DIANA-TarBase v7.0 (http://www.microrna.gr/tarbase) aims to provide for the first time hundreds of thousands of high-quality manually curated experimentally validated miRNA:gene interactions, enhanced with detailed meta-data. DIANA-TarBase v7.0 enables users to easily identify positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment. The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments. More than half a million miRNA:gene interactions have been curated from published experiments on 356 different cell types from 24 species, corresponding to 9- to 250-fold more entries than any other relevant database. DIANA-TarBase v7.0 is freely available.

PMID:
25416803
PMCID:
PMC4383989
DOI:
10.1093/nar/gku1215
[Indexed for MEDLINE]
Free PMC Article

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