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Viruses. 2014 Nov 19;6(11):4479-504. doi: 10.3390/v6114479.

Mosquito immunity against arboviruses.

Author information

1
Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore. shuzhens@gis.a-star.edu.sg.
2
Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA. njupata1@jhu.edu.
3
Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA. gdimopo1@jhu.edu.

Abstract

Arthropod-borne viruses (arboviruses) pose a significant threat to global health, causing human disease with increasing geographic range and severity. The recent availability of the genome sequences of medically important mosquito species has kick-started investigations into the molecular basis of how mosquito vectors control arbovirus infection. Here, we discuss recent findings concerning the role of the mosquito immune system in antiviral defense, interactions between arboviruses and fundamental cellular processes such as apoptosis and autophagy, and arboviral suppression of mosquito defense mechanisms. This knowledge provides insights into co-evolutionary processes between vector and virus and also lays the groundwork for the development of novel arbovirus control strategies that target the mosquito vector.

PMID:
25415198
PMCID:
PMC4246235
DOI:
10.3390/v6114479
[Indexed for MEDLINE]
Free PMC Article

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