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Nucleic Acids Res. 2015 Jan;43(Database issue):D946-55. doi: 10.1093/nar/gku1086. Epub 2014 Nov 20.

EHFPI: a database and analysis resource of essential host factors for pathogenic infection.

Author information

1
Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R.China.
2
Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R.China No. 451 Hospital of Chinese People's Liberation Army, Xi'an 710054, China huibai13@hotmail.com.
3
Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R.China lifei@bmi.ac.cn.
4
Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R.China boxc@bmi.ac.cn.

Abstract

High-throughput screening and computational technology has greatly changed the face of microbiology in better understanding pathogen-host interactions. Genome-wide RNA interference (RNAi) screens have given rise to a new class of host genes designated as Essential Host Factors (EHFs), whose knockdown effects significantly influence pathogenic infections. Therefore, we present the first release of a manually-curated bioinformatics database and analysis resource EHFPI (Essential Host Factors for Pathogenic Infection, http://biotech.bmi.ac.cn/ehfpi). EHFPI captures detailed article, screen, pathogen and phenotype annotation information for a total of 4634 EHF genes of 25 clinically important pathogenic species. Notably, EHFPI also provides six powerful and data-integrative analysis tools, i.e. EHF Overlap Analysis, EHF-pathogen Network Analysis, Gene Enrichment Analysis, Pathogen Interacting Proteins (PIPs) Analysis, Drug Target Analysis and GWAS Candidate Gene Analysis, which advance the comprehensive understanding of the biological roles of EHF genes, as in diverse perspectives of protein-protein interaction network, drug targets and diseases/traits. The EHFPI web interface provides appropriate tools that allow efficient query of EHF data and visualization of custom-made analysis results. EHFPI data and tools shall keep available without charge and serve the microbiology, biomedicine and pharmaceutics research communities, to finally facilitate the development of diagnostics, prophylactics and therapeutics for human pathogens.

PMID:
25414353
PMCID:
PMC4383917
DOI:
10.1093/nar/gku1086
[Indexed for MEDLINE]
Free PMC Article

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