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Nucleic Acids Res. 2015 Jan;43(Database issue):D784-8. doi: 10.1093/nar/gku1166. Epub 2014 Nov 20.

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.

Author information

1
Institute of Integrative Biology, University of Liverpool, Liverpool, UK Center for Biomedical Research, Faculty of Medicine, Autonomous University of Coahuila, Torreon, Mexico.
2
Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
3
Institute of Integrative Biology, University of Liverpool, Liverpool, UK Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil.
4
Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil.
5
Institute of Integrative Biology, University of Liverpool, Liverpool, UK Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
6
Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
7
Institute of Integrative Biology, University of Liverpool, Liverpool, UK Andrew.Jones@liv.ac.uk.
8
Transplant Immunology Laboratory, Royal Liverpool and Broadgreen University Hospital, University of Liverpool, UK Institute of Infection and Global Health, University of Liverpool, UK.

Abstract

It has been 12 years since the Allele Frequency Net Database (AFND; http://www.allelefrequencies.net) was first launched, providing the scientific community with an online repository for the storage of immune gene frequencies in different populations across the world. There have been a significant number of improvements from the first version, making AFND a primary resource for many clinical and scientific areas including histocompatibility, immunogenetics, pharmacogenetics and anthropology studies, among many others. The most widely used part of AFND stores population frequency data (alleles, genes or haplotypes) related to human leukocyte antigens (HLA), killer-cell immunoglobulin-like receptors (KIR), major histocompatibility complex class I chain-related genes (MIC) and a number of cytokine gene polymorphisms. AFND now contains >1400 populations from more than 10 million healthy individuals. Here, we report how the main features of AFND have been updated to include a new section on 'HLA epitope' frequencies in populations, a new section capturing the results of studies identifying HLA associations with adverse drug reactions (ADRs) and one for the examination of infectious and autoimmune diseases associated with KIR polymorphisms-thus extending AFND to serve a new user base in these growing areas of research. New criteria on data quality have also been included.

PMID:
25414323
PMCID:
PMC4383964
DOI:
10.1093/nar/gku1166
[Indexed for MEDLINE]
Free PMC Article

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