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Crit Rev Biochem Mol Biol. 2015 Jan-Feb;50(1):54-68. doi: 10.3109/10409238.2014.985816. Epub 2014 Nov 21.

Next generation mothers: Maternal control of germline development in zebrafish.

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Institut für Entwicklungsbiochemie, GZMB, Universitätsmedizin Göttingen, Georg-August-Universität , Göttingen , Germany.


In many animals, factors deposited by the mother into the egg control the earliest events in development of the zygote. These maternal RNAs and proteins play critical roles in oocyte development and the earliest steps of embryogenesis such as fertilization, cell division and embryonic patterning. Here, this article summarizes recent discoveries made on the maternal control of germline specification in zebrafish. Moreover, this review will discuss the major gaps remaining in our understanding of this process and highlight recent technical innovations in zebrafish, which allow tackling some of these questions in the near future.


Early embryogenesis; gamete; genetics; germ cell; germ plasm; maternal-effect; oocyte; oogenesis

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