Format

Send to

Choose Destination
Neurodegener Dis. 2014;14(4):161-75. doi: 10.1159/000367694. Epub 2014 Nov 20.

Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.

Author information

1
Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, Ala., USA.

Abstract

The ubiquitin proteasome system (UPS) is the primary proteolytic quality control system in cells and has an essential function in the nervous system. UPS dysfunction has been linked to neurodegenerative conditions, including Alzheimer's, Parkinson's and Huntington's diseases. The pathology of neurodegenerative diseases is characterized by the abnormal accumulation of insoluble protein aggregates or inclusion bodies within neurons. The failure or dysregulation of the UPS prevents the degradation of misfolded/aberrant proteins, leading to deficient synaptic function that eventually affects the nervous system. In this review, we discuss the UPS and its physiological roles in the nervous system, its influence on neuronal function, and how UPS dysfunction contributes to the development of neurodegenerative diseases.

PMID:
25413678
DOI:
10.1159/000367694
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center