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ACS Comb Sci. 2015 Jan 12;17(1):24-31. doi: 10.1021/co500120b. Epub 2014 Dec 2.

Efficient synthesis and evaluation of antitumor activities of novel functionalized 1,8-naphthyridine derivatives.

Author information

1
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.

Abstract

An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.

KEYWORDS:

1,8-naphthyridine; antitumor activity; cascade reaction; chromeno[2,3-b]quinoline

PMID:
25412896
DOI:
10.1021/co500120b
[Indexed for MEDLINE]

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