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J Exp Med. 1989 May 1;169(5):1557-64.

Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain.

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Department of Pediatrics, Stanford University School of Medicine, California 94305.


CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.

[Indexed for MEDLINE]
Free PMC Article

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