Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes

Dale Lawson; Alessandro Barge; Enzo Terreno; David Parker; Silvio Aime; Mauro Botta

doi:10.1039/c4dt02971b

Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes

Dalton Trans. 2015 Mar 21;44(11):4910-7. doi: 10.1039/c4dt02971b.

Authors

Dale Lawson¹, Alessandro Barge, Enzo Terreno, David Parker, Silvio Aime, Mauro Botta

Affiliation

¹ Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza, 52, 10126, Torino, Italy.

PMID: 25411928
DOI: 10.1039/c4dt02971b

Abstract

Using recognition moieties that bind to the inner co-ordination sphere of a monomeric DO3A-type di-aqua complex, dimeric poly(aminocarboxylate) gadolinium(III) compounds can be formed with greatly enhanced relaxivities, arising from optimized contributions of inner- and second spheres of hydration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Contrast Media / chemistry*
Gadolinium / chemistry*
Macrocyclic Compounds / chemistry*
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Organometallic Compounds / chemistry*
Water / chemistry

Substances

Contrast Media
Macrocyclic Compounds
Organometallic Compounds
Water
Gadolinium