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Lupus. 2015 May;24(6):606-12. doi: 10.1177/0961203314559628. Epub 2014 Nov 18.

Lack of association between serum 25-hydroxyvitamin D levels and cervical human papillomavirus infection in systemic lupus erythematosus.

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Systemic Autoimmune Diseases Research Unit, HGR #36-CIBIOR, IMSS, Puebla, Mexico Department of Immunology and Rheumatology, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Systemic Autoimmune Diseases Research Unit, HGR #36-CIBIOR, IMSS, Puebla, Mexico.
Laboratorios Clínicos de Puebla, Puebla, Mexico.
Instituto Mexicano del Seguro Social (IMSS), Centro de Investigación Biomédica de Oriente (CIBIOR), Molecular Biology and Virology Laboratory, Metepec, Puebla, Mexico.
Benemérita Universidad Autónoma de Puebla, Medicine School, Research and Posgraduate, Studies Secretary, Puebla, Mexico.
Department of Microbiology and Virology, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
State Research Department, Research Unit, IMSS, Puebla, Mexico.
Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain


Our objective was to evaluate whether vitamin D deficiency is associated with cervical human papilloma virus (HPV) infection in women with SLE. This is a cross-sectional study of 67 women with SLE. A structured questionnaire was administered to ascertain the possible risk factors associated with cervical HPV infection. A gynaecological evaluation and cervical cytology screening were made. HPV detection and genotyping was made by PCR and linear array assay. Serum 25 hydroxyvitamin D levels were quantified by chemiluminescence immunoassay. Mean age and disease duration were 44.8 ± 10.6 and 42.5 ± 11.8 years, respectively. Demographic characteristics were similar in patients with and without deficiency (<20 ng/ml and ≥20 ng/ml). There were 28.4% of women with cervical HPV infection and 68.4% had high-risk HPV infections. Patients with 25 hydroxyvitamin D levels <20 ng/ml had a higher prevalence of cervical HPV infection than those with levels ≥20 ng/ml (30.7% vs. 25.8%; p = 0.72). We found no significant difference when high-risk HPV infection was evaluated (36.8% vs. 31.5%; p = 0.73). In conclusion, women with SLE have a high prevalence of vitamin D deficiency and cervical HPV infection. However, we found no association between vitamin D deficiency and cervical HPV.


Cervical human papillomavirus infection; systemic lupus erythematosus; vitamin D

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