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Pharmacogenomics. 2014 Sep;15(13):1687-700. doi: 10.2217/pgs.14.121.

Genetic polymorphisms and response to medications for alcohol use disorders: a systematic review and meta-analysis.

Author information

1
University of North Carolina at Chapel Hill, Department of Medicine, 5034 Old Clinic Building, CB #7110, Chapel Hill, NC 27599, USA.

Abstract

AIM:

To assess whether response to medications for alcohol use disorders varies by genotype.

METHODS:

Systematic review and meta-analysis.

RESULTS:

We found no studies that assessed the clinical utility of genotype-guided dosing strategies or genotype-guided medication selection, and none randomized by genotype. All included studies assessed the association between genotype and response to medication. Of 15 included studies, eight (n = 1365 participants) assessed variation in naltrexone response and polymorphisms of OPRM1. Our meta-analyses for return to heavy drinking found no significant difference between A allele homozygotes and those with at least one G allele, both without (risk difference: 0.26; 95% CI: -0.01-0.53; n = 174) and with inclusion of studies rated as high or unclear risk of bias (risk difference: 0.14; 95% CI: -0.03-0.3; n = 382). For all other polymorphism-medication pairs, we found just one eligible study.

CONCLUSION:

Estimates of effect for return to heavy drinking suggest it is possible that patients with at least one G allele of A118G polymorphism of OPRM1 might be more likely to respond to naltrexone, but confidence intervals were wide; additional studies are needed to improve confidence in the estimates.

KEYWORDS:

OPRM1; alcohol; alcohol dependence; alcohol use disorder; naltrexone; opioid receptor; pharmacogenomics; polymorphism; systematic review

PMID:
25410894
DOI:
10.2217/pgs.14.121
[Indexed for MEDLINE]

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