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J Virol. 2015 Feb;89(3):1909-12. doi: 10.1128/JVI.02611-14. Epub 2014 Nov 19.

Global displacement of canine parvovirus by a host-adapted variant: structural comparison between pandemic viruses with distinct host ranges.

Author information

1
Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
2
Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
3
Macromolecular Diffraction Facility at CHESS (MacCHESS), Cornell University, Ithaca, New York, USA.
4
Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA shafenstein@hmc.psu.edu.

Abstract

Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.

PMID:
25410876
PMCID:
PMC4300749
DOI:
10.1128/JVI.02611-14
[Indexed for MEDLINE]
Free PMC Article

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