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J Clin Pathol. 2015 Feb;68(2):135-40. doi: 10.1136/jclinpath-2014-202681. Epub 2014 Nov 19.

Type-specific HPV prevalence in invasive cervical cancer in the UK prior to national HPV immunisation programme: baseline for monitoring the effects of immunisation.

Author information

1
Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK.
2
Scottish HPV Reference Lab, Royal Infirmary of Edinburgh, Edinburgh, UK.
3
HPV Research Group, School of Medicine, Cardiff University, Cardiff, UK.
4
Cellular and Molecular Pathology Department, Antrim Hospital, Northern Health and Social Care Trust, Co. Antrim, UK.
5
Manchester Virology Laboratory, Public Health England, Manchester, UK.
6
Health Protection Scotland, Glasgow, UK.

Abstract

AIMS:

To establish the human papillomavirus (HPV) type-specific prevalence in cervical cancer and high-grade cervical lesions in the UK prior to the introduction of national HPV vaccination.

METHODS:

Specimens of cervical cancer (n=1235) and cervical intraepithelial neoplasia (CIN)3 (n=2268) were tested for HPV genotypes in England, Scotland, Wales and Northern Ireland. Data were pooled and weighted estimates presented.

RESULTS:

Among cervical cancer cases, 95.8% were positive for at least one high-risk (HR) HPV type. Restricting to those with HR HPV, the proportion positive for HPV16 and/or HPV18 was similar across countries (weighted overall prevalence 83.0%). This proportion decreased with increasing age at diagnosis (p=0.0005). HPV31, HPV33, HPV45, HPV52 and/or HPV58 were detected in 16.1% of HR HPV-positive cervical cancers and there was no significant association with age for these types. For HR HPV-positive CIN3 cases, there was a similar age-specific pattern with the highest positivity of HPV16 and/or HPV18 in the youngest age group (77.2%). The proportion of HR HPV CIN3 cases positive for HPV31, HPV33, HPV45, HPV52 and/or HPV58 was 36.3% in those aged <30 years at diagnosis.

CONCLUSIONS:

The prevalence of HPV 16 and/or 18 was high in all UK countries and highest in those diagnosed at a younger age. The UK is well placed to monitor the impact of HPV vaccination on type-specific HPV prevalence in cervical disease.

KEYWORDS:

CERVICAL CANCER; HPV; PAPILLOMA VIRUSES

PMID:
25410654
DOI:
10.1136/jclinpath-2014-202681
[Indexed for MEDLINE]

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