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Nat Rev Neurosci. 2014 Dec;15(12):786-801. doi: 10.1038/nrn3846.

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.

Author information

1
1] School of Medicine and Center of Integrated Research, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, I-00128 Rome, Italy. [2] European Center for Brain Research/Santa Lucia Foundation, Via del Fosso di Fiorano 65, I-00143 Rome, Italy.
2
Department of Biochemistry and Molecular Biology I and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, E-28040 Madrid, Spain.
3
Department of Psychological and Brain Sciences, Indiana University, 702 N Walnut Grove Avenue, Bloomington, Indiana 47405-2204, USA.
4
Wolfson Centre for Age-Related Diseases, King's College, London SE1 1UL, United Kingdom.
5
1] Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1:A1, Karolinska Institutet, SE-17177 Stockholm, Sweden. [2] Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria.

Abstract

Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms and contribute to the public debate about the benefits and the risks of cannabis use during pregnancy and in adolescence.

PMID:
25409697
PMCID:
PMC4765324
DOI:
10.1038/nrn3846
[Indexed for MEDLINE]
Free PMC Article

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