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J Med Life. 2014 Sep 15;7(3):322-6. Epub 2014 Sep 25.

Retinal toxicity associated with chronic exposure to hydroxychloroquine and its ocular screening. Review.

Author information

1
Ophthalmology Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest.
2
"Victor Babeș"' National Institute of Pathology, Bucharest.
3
"Foisor" Traumatology and Orthopedics Clinical Hospital, Bucharest.

Abstract

Hydroxychloroquine sulfate (HCQ, Plaquenil) is an analogue of chloroquine (CQ), an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Because it presents potential secondary effects including irreversible maculopathy, knowledge of incidence, risk factors, drug toxicity and protocol screening of the patients it represents important data for the ophthalmologists. Thus, it is imperative that rheumatologists, medical internists and ophthalmologists are aware of the toxicity from hydroxychloroquine they should also be careful to minimize its occurrence and effects.

KEYWORDS:

bull’s eye maculopathy; hydroxychloroquine sulfate; screening tool

PMID:
25408748
PMCID:
PMC4233433
[Indexed for MEDLINE]
Free PMC Article

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