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Bioessays. 1989 Jan;10(1):16-9.

Atrial natriuretic peptides: receptors and second messengers.

Abstract

Atrial natriuretic peptides appear to elicit their actions in some target tissues by binding to a novel cell-surface transmembrane protein which possesses both peptide binding and guanylate cyclase activities. Ligand binding stimulates enzyme activity to produce increased intracellular concentrations of cyclic GMP which, in turn, mediates the cell's physiological response.

PMID:
2540738
DOI:
10.1002/bies.950100105
[Indexed for MEDLINE]
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