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BMC Psychiatry. 2014 Nov 19;14:321. doi: 10.1186/s12888-014-0321-9.

Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies.

Su L1,2, Cai Y3,4, Xu Y5, Dutt A6, Shi S7,8, Bramon E9,10.

Author information

  • 1Department of Psychiatry, Huashan Hospital, Fudan University, School of Medicine, No. 12 Wulumuqi Road (middle), Shanghai, 200040, People's Republic of China. lsu@fudan.edu.cn.
  • 2Department of Psychosis studies, Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK. lsu@fudan.edu.cn.
  • 3Department of Psychiatry, Huashan Hospital, Fudan University, School of Medicine, No. 12 Wulumuqi Road (middle), Shanghai, 200040, People's Republic of China. caiyiyuncyy@gmail.com.
  • 4Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. caiyiyuncyy@gmail.com.
  • 5Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hyyyyb@gmail.com.
  • 6Department of Psychosis studies, Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK. anirban.dutt@kcl.ac.uk.
  • 7Department of Psychiatry, Huashan Hospital, Fudan University, School of Medicine, No. 12 Wulumuqi Road (middle), Shanghai, 200040, People's Republic of China. shishenxun@163.com.
  • 8Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. shishenxun@163.com.
  • 9Department of Psychosis studies, Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK. e.bramon@ucl.ac.uk.
  • 10Mental Health Sciences Unit & Institute of Cognitive Neuroscience, University College London, London, UK. e.bramon@ucl.ac.uk.

Abstract

BACKGROUND:

Major depressive disorder (MDD) is a common mental illness with high lifetime prevalence close to 20%. Positron emission tomography (PET) studies have reported decreased prefrontal, insular and limbic cerebral glucose metabolism in depressed patients compared with healthy controls. However, the literature has not always been consistent. To evaluate current evidence from PET studies, we conducted a voxel-based meta-analysis of cerebral metabolism in MDD.

METHOD:

Data were collected from databases including PubMed and Web of Science, with the last report up to April 2013. Voxel-based meta-analyses were performed using the revised activation likelihood estimation (ALE) software.

RESULTS:

Ten whole-brain-based FDG-PET studies in MDD were included in the meta-analysis, comprising 188 MDD patients and 169 healthy controls. ALE analyses showed the brain metabolism in bilateral insula, left lentiform nucleus putamen and extra-nuclear, right caudate and cingulate gyrus were significantly decreased. However, the brain activity in right thalamus pulvinar and declive of posterior lobe, left culmen of vermis in anterior lobe were significantly increased in MDD patients.

CONCLUSION:

Our meta-analysis demonstrates the specific brain regions where possible dysfunctions are more consistently reported in MDD patients. Altered metabolism in insula, limbic system, basal ganglia, thalamus, and cerebellum and thus these regions are likely to play a key role in the pathophysiology of depression.

PMID:
25407081
PMCID:
PMC4240898
DOI:
10.1186/s12888-014-0321-9
[PubMed - indexed for MEDLINE]
Free PMC Article
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