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Neuroendocrinology. 2014;100(2-3):95-102. doi: 10.1159/000369072. Epub 2014 Nov 6.

Agouti-related protein neuron circuits that regulate appetite.

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1
Janelia Research Campus, HHMI, Ashburn, Va., USA.

Abstract

New tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Studies that focused on Agouti-related protein neurons, a starvation-sensitive hypothalamic population, have identified multiple circuit elements that can elicit or suppress feeding behavior. Distinct axon projections of this neuron population point to different circuits that regulate long-term appetite, short-term feeding, or visceral malaise-mediated anorexia. Here, we review recent studies examining these neural circuits that control food intake.

PMID:
25402352
DOI:
10.1159/000369072
[Indexed for MEDLINE]
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