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Biomed Opt Express. 2014 Aug 15;5(9):3059-73. doi: 10.1364/BOE.5.003059. eCollection 2014 Sep 1.

Non-common path aberration correction in an adaptive optics scanning ophthalmoscope.

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The Institute of Optics, University of Rochester, Rochester, New York 14627, USA.
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 USA ; Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53223, USA ; Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53223, USA.


The correction of non-common path aberrations (NCPAs) between the imaging and wavefront sensing channel in a confocal scanning adaptive optics ophthalmoscope is demonstrated. NCPA correction is achieved by maximizing an image sharpness metric while the confocal detection aperture is temporarily removed, effectively minimizing the monochromatic aberrations in the illumination path of the imaging channel. Comparison of NCPA estimated using zonal and modal orthogonal wavefront corrector bases provided wavefronts that differ by ~λ/20 in root-mean-squared (~λ/30 standard deviation). Sequential insertion of a cylindrical lens in the illumination and light collection paths of the imaging channel was used to compare image resolution after changing the wavefront correction to maximize image sharpness and intensity metrics. Finally, the NCPA correction was incorporated into the closed-loop adaptive optics control by biasing the wavefront sensor signals without reducing its bandwidth.


(110.1080) Active or adaptive optics; (170.4460) Ophthalmic optics and devices

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