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World J Gastrointest Pathophysiol. 2014 Nov 15;5(4):496-513. doi: 10.4291/wjgp.v5.i4.496.

Zinc and gastrointestinal disease.

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Sonja Skrovanek, Katherine DiGuilio, James M Mullin, Lankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA 19096, United States.


This review is a current summary of the role that both zinc deficiency and zinc supplementation can play in the etiology and therapy of a wide range of gastrointestinal diseases. The recent literature describing zinc action on gastrointestinal epithelial tight junctions and epithelial barrier function is described. Zinc enhancement of gastrointestinal epithelial barrier function may figure prominently in its potential therapeutic action in several gastrointestinal diseases.


Micronutrient; Nutraceutical; Nutrition; Tight junction; Zinc

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