Format

Send to

Choose Destination
FEBS J. 2015 Feb;282(4):630-46. doi: 10.1111/febs.13150. Epub 2014 Dec 2.

BRCA1, a 'complex' protein involved in the maintenance of genomic stability.

Author information

1
Centre for Cancer Research and Cell Biology, Queen's University Belfast, UK.

Abstract

BRCA1 is a major breast and ovarian cancer susceptibility gene, with mutations in this gene predisposing women to a very high risk of developing breast and ovarian tumours. BRCA1 primarily functions to maintain genomic stability via critical roles in DNA repair, cell cycle checkpoint control, transcriptional regulation, apoptosis and mRNA splicing. As a result, BRCA1 mutations often result in defective DNA repair, genomic instability and sensitivity to DNA damaging agents. BRCA1 carries out these different functions through its ability to interact, and form complexes with, a vast array of proteins involved in multiple cellular processes, all of which are considered to contribute to its function as a tumour suppressor. This review discusses and highlights recent research into the functions of BRCA1-related protein complexes and their roles in maintaining genomic stability and tumour suppression.

KEYWORDS:

BRCA1; DNA damage response; DNA repair; breast cancer; genomic instability; hereditary breast cancer

PMID:
25400280
DOI:
10.1111/febs.13150
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center